SIRT1/DNMT3B-mediated epigenetic gene silencing in response to phytoestrogens in mammary epithelial cells
We performed an integrated analysis of genome-wide DNA methylation and expression datasets in normal cells and healthy animals exposed to polyphenols Bondage with estrogenic activity (i.e.phytoestrogens).We identified that phytoestrogens target genes linked to disrupted cellular homeostasis, e.g.genes limiting DNA break repair (RNF169) or promoting